Whole genome sequence (WGS) and clinical data for the orofacial cleft (OFC) birth defects in Latin American families study (Accession: phs001420) are now available to the biomedical research community through the NIH’s Database of Genotypes and Phenotypes (dbGaP) and the Kids First Data Resource Portal. 

OFCs are among the most common birth defects that occur when a baby’s lip, palate, or both do not form properly during pregnancy. The goal of this project led by Dr. Mary L. Marazita of the University of Pittsburgh Center for Craniofacial and Dental Genetics, is to identify genetic variants causing OFC.  

To access and analyze this dataset apply for access through NIH’s dbGaP at https://www.ncbi.nlm.nih.gov/gap. Once approved, a user will receive instructions from dbGaP on how to access the data housed by the Gabriella Miller Kids First Data Resource Center. For help with this dataset, you may contact [email protected].