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bioRxiv : the preprint server for biology |
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bioRxiv |
2024 Dec 9 |
Ligand identification in CryoEM and X-ray maps using deep learning. |
Karolczak J, Przybyłowska A, Szewczyk K, Taisner W, Heumann JM, Stowell MHB, Nowicki M, Brzezinski D |
Bioinformatics (Oxford, England) |
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2024 Dec 26 |
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Nature structural & molecular biology |
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Nat Struct Mol Biol |
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2022 Nov 5 |
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2022 Apr 6 |
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Molecular cell |
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2022 Jan 20 |
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2021 Sep 13 |
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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada |
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2023 Dec 21 |
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Nature communications |
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2024 Jul 14 |
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Current opinion in structural biology |
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Nature methods |
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Nat Methods |
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microPublication biology |
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bioRxiv : the preprint server for biology |
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High-Resolution Cryo-EM Structure Determination of α-synuclein - A Prototypical Amyloid Fibril. |
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bioRxiv : the preprint server for biology |
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Handling difficult cryo-ET samples: A study with primary neurons from Drosophila melanogaster. |
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bioRxiv : the preprint server for biology |
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mBio |
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In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET. |
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bioRxiv : the preprint server for biology |
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2024 Mar 27 |
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Proceedings of the National Academy of Sciences of the United States of America |
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Science (New York, N.Y.) |
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2022 Jun 10 |
Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication. |
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Sci Rep |
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2022 Sep 14 |
Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide. |
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2022 May 18 |
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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography. |
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Proc Natl Acad Sci U S A |
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Structure of the human Mediator-bound transcription preinitiation complex. |
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Science (New York, N.Y.) |
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A Robust Single-Particle Cryo-Electron Microscopy (cryo-EM) Processing Workflow with cryoSPARC, RELION, and Scipion. |
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2022 Feb 15 |
Structural basis for flagellin induced NAIP5 activation. |
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Energy Coupling and Stoichiometry of Zn(2+)/H(+) Antiport by the Cation Diffusion Facilitator YiiP. |
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bioRxiv : the preprint server for biology |
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ACS nano |
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Science advances |
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Cryo-EM reveals the molecular basis oflaminin polymerization and LN-lamininopathies. |
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Nature communications |
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Nature communications |
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2023 Apr 28 |
Cryo-EM Structure of AAV2 Rep68 bound to integration site AAVS1: Insights into the mechanism of DNA melting. |
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bioRxiv : the preprint server for biology |
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Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. |
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RNA (New York, N.Y.) |
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Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin. |
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2024 Mar 14 |
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2024 Mar 7 |
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The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors. |
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Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus. |
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Nature |
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2023 Jan |
Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. |
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Nature communications |
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2023 Oct 11 |
Antiviral drug recognition and elevator-type transport motions of CNT3. |
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Nature chemical biology |
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Nat Chem Biol |
2024 Sep |
Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. |
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2024 Apr 23 |
Amyloid fibril polymorphism in the heart of an ATTR amyloidosis patient with polyneuropathy attributed to the V122Δ variant. |
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bioRxiv : the preprint server for biology |
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2024 May 10 |
ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity. |
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bioRxiv : the preprint server for biology |
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2024 May 14 |
Structure of an open K(ATP) channel reveals tandem PIP(2) binding sites mediating the Kir6.2 and SUR1 regulatory interface. |
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Nature communications |
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Nat Commun |
2024 Mar 20 |
Structure of the human dopamine transporter and mechanisms of inhibition. |
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Nature |
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2024 Aug |
AI-Based Discovery and CryoEM Structural Elucidation of a K(ATP) Channel Pharmacochaperone. |
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bioRxiv : the preprint server for biology |
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Streptococcus pneumoniae GAPN is a key metabolic player necessary for host infection. |
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2024 Oct 1 |
Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels. |
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Nature communications |
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2024 Nov 26 |
Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket. |
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2025 Jan 17 |
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Structural basis for human NKCC1 inhibition by loop diuretic drugs. |
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The EMBO journal |
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Cryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting. |
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Methods in enzymology |
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TRPV3 expression and purification for structure determination by Cryo-EM. |
Neuberger A, Nadezhdin KD, Sobolevsky AI |
Methods in enzymology |
34059288 |
Methods Enzymol |
2021 |
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. |
Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H |
Nature communications |
33420033 |
Nat Commun |
2021 Jan 8 |
Architecture and assembly mechanism of native glycine receptors. |
Zhu H, Gouaux E |
Nature |
34555840 |
Nature |
2021 Nov |
Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities. |
Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE |
Nature communications |
35933426 |
Nat Commun |
2022 Aug 6 |
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. |
Paidimuddala B, Cao J, Nash G, Xie Q, Wu H, Zhang L |
Nature structural & molecular biology |
36604500 |
Nat Struct Mol Biol |
2023 Feb |
A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases. |
Redzic JS, Rahkola J, Tran N, Holyoak T, Lee E, Martín-Galiano AJ, Meyer N, Zheng H, Eisenmesser E |
Communications biology |
36336763 |
Commun Biol |
2022 Nov 7 |
The promise of cryo-EM to explore RNA structural dynamics. |
Bonilla SL, Kieft JS |
Journal of molecular biology |
36049551 |
J Mol Biol |
2022 Sep 30 |
Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3. |
Fry MY, Najdrová V, Maggiolo AO, Saladi SM, Doležal P, Clemons WM Jr |
Nature structural & molecular biology |
35851188 |
Nat Struct Mol Biol |
2022 Aug |
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC. |
Srinivas P, Nosrati M, Zelinskaya N, Dey D, Comstock LR, Dunham CM, Conn GL |
bioRxiv : the preprint server for biology |
36993224 |
bioRxiv |
2023 Apr 30 |
Structural basis of sensory receptor evolution in octopus. |
Allard CAH, Kang G, Kim JJ, Valencia-Montoya WA, Hibbs RE, Bellono NW |
Nature |
37045920 |
Nature |
2023 Apr |
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. |
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Cancer discovery |
35658124 |
Cancer Discov |
2022 Aug 5 |
Methotrexate recognition by the human reduced folate carrier SLC19A1. |
Wright NJ, Fedor JG, Zhang H, Jeong P, Suo Y, Yoo J, Hong J, Im W, Lee SY |
Nature |
36071163 |
Nature |
2022 Sep |
An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii. |
Morgan CE, Zhang Z, Bonomo RA, Yu EW |
mBio |
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mBio |
2021 Feb 22 |
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Andreeva L, David L, Rawson S, Shen C, Pasricha T, Pelegrin P, Wu H |
Cell |
34861190 |
Cell |
2021 Dec 22 |
Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer. |
Hu W, Zheng H |
Communications biology |
34887516 |
Commun Biol |
2021 Dec 9 |
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. |
Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S |
Molecular cell |
33373584 |
Mol Cell |
2021 Feb 4 |
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. |
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Neuron |
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Neuron |
2021 Jan 20 |
Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer. |
Koo CW, Tucci FJ, He Y, Rosenzweig AC |
Science (New York, N.Y.) |
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Science |
2022 Mar 18 |
Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. |
Yang C, Fujiwara R, Kim HJ, Basnet P, Zhu Y, Gorbea Colón JJ, Steimle S, Garcia BA, Kaplan CD, Murakami K |
Molecular cell |
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Mol Cell |
2022 Feb 3 |
Structural Basis for Virulence Activation of Francisella tularensis. |
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Molecular cell |
33217319 |
Mol Cell |
2021 Jan 7 |
Structural insights into opposing actions of neurosteroids on GABA(A) receptors. |
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Nature communications |
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Nat Commun |
2023 Aug 22 |
Structure and assembly of a bacterial gasdermin pore. |
Johnson AG, Mayer ML, Schaefer SL, McNamara-Bordewick NK, Hummer G, Kranzusch PJ |
bioRxiv : the preprint server for biology |
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bioRxiv |
2023 Oct 26 |
Structures of the TMC-1 complex illuminate mechanosensory transduction. |
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Nature |
36224384 |
Nature |
2022 Oct |
Transient Prenyltransferase-Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase. |
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Biochemistry |
36227241 |
Biochemistry |
2022 Nov 1 |
Cryo-EM structure of a thermostable bacterial nanocompartment. |
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IUCrJ |
33953921 |
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2021 May 1 |
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Nature structural & molecular biology |
36482249 |
Nat Struct Mol Biol |
2022 Dec |
A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability. |
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Structure (London, England : 1993) |
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2023 Mar 2 |
The molecular mechanism of sialic acid transport mediated by Sialin. |
Hu W, Chi C, Song K, Zheng H |
Science advances |
36662855 |
Sci Adv |
2023 Jan 20 |
C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA. |
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bioRxiv : the preprint server for biology |
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2024 Jan 24 |
Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. |
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Science advances |
37256947 |
Sci Adv |
2023 Jun 2 |
Virion glycosylation influences mycobacteriophage immune recognition. |
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Cell host & microbe |
37329881 |
Cell Host Microbe |
2023 Jul 12 |
Energy coupling and stoichiometry of Zn(2+)/H(+) antiport by the prokaryotic cation diffusion facilitator YiiP. |
Hussein A, Fan S, Lopez-Redondo M, Kenney I, Zhang X, Beckstein O, Stokes DL |
eLife |
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2023 Oct 31 |
ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity. |
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Structure (London, England : 1993) |
39423808 |
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2024 Dec 5 |
Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain. |
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Nature communications |
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Nat Commun |
2024 Nov 7 |
Structural basis for Retriever-SNX17 assembly and endosomal sorting. |
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Nature communications |
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Nat Commun |
2024 Nov 25 |
High-affinity agonism at the P2X(7) receptor is mediated by three residues outside the orthosteric pocket. |
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Nature communications |
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Nat Commun |
2024 Aug 6 |
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RNA (New York, N.Y.) |
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2024 Oct 16 |
A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion. |
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bioRxiv : the preprint server for biology |
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2024 Oct 21 |
Structures of the essential efflux pump EfpA from Mycobacterium tuberculosis reveal the mechanisms of substrate transport and small-molecule inhibition. |
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Research square |
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2024 Jan 5 |
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Nature |
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2024 Jan |
The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. |
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Nature communications |
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2024 Apr 17 |
Kainate receptor channel opening and gating mechanism. |
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Nature |
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2024 Jun |
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. |
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bioRxiv : the preprint server for biology |
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2024 Mar 9 |
Structural basis for Retriever-SNX17 assembly and endosomal sorting. |
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bioRxiv : the preprint server for biology |
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bioRxiv |
2024 Mar 13 |
Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA. |
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eLife |
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2024 May 15 |
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Nature communications |
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2023 Jun 23 |
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Nature communications |
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2024 Aug 9 |
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Nature communications |
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2024 Aug 14 |
Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. |
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Communications biology |
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Commun Biol |
2024 Jun 17 |
Structural insights into GABA(A) receptor potentiation by Quaalude. |
Chojnacka W, Teng J, Kim JJ, Jensen AA, Hibbs RE |
Nature communications |
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2024 Jun 19 |
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eLife |
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2024 May 29 |
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Nature communications |
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2024 Sep 4 |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2024 Jul 2 |
Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants. |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2023 Jul 18 |
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2023 May 27 |
Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation. |
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Molecular cell |
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Mol Cell |
2023 Aug 3 |
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2023 Mar 2 |
Structural Determination of Glucosyltransferase C by Cryo-Electron Microscopy. |
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Methods in molecular biology (Clifton, N.J.) |
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Methods Mol Biol |
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Molecular & cellular proteomics : MCP |
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Mol Cell Proteomics |
2023 Dec |
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Nature |
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2024 Jan |
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Nature communications |
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2023 Dec 27 |
Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery. |
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Biomaterials science |
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Biomater Sci |
2021 Jun 15 |
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Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. |
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Nature communications |
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2021 Mar 29 |
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM. |
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2021 Jun 3 |
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Nature |
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2021 Jun |
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. |
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Nature |
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2021 Apr |
Mechanism of Ca(2+) transport by ferroportin. |
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2023 Jan 17 |
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Gating choreography and mechanism of the human proton-activated chloride channel ASOR. |
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Science advances |
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Sci Adv |
2022 Feb 4 |
Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. |
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Nature communications |
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Nat Commun |
2021 Oct 8 |
Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery. |
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2020 Jun 10 |
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bioRxiv : the preprint server for biology |
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2023 Oct 9 |
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Journal of molecular biology |
37952769 |
J Mol Biol |
2023 Dec 15 |
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. |
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2023 Aug 31 |
Cryo-EM analysis of Pseudomonas phage Pa193 structural components. |
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2024 Apr 12 |
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Nature communications |
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2024 Apr 29 |
Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution. |
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Nature structural & molecular biology |
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Nat Struct Mol Biol |
2024 Oct |
Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance. |
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Science advances |
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Sci Adv |
2024 Mar |
Anti-Immune Complex Antibodies are Elicited During Repeated Immunization with HIV Env Immunogens. |
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2024 Mar 17 |
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2024 Mar 6 |
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Nature |
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2024 Apr |
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Science (New York, N.Y.) |
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2022 Oct 14 |
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Nature communications |
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2020 Feb 21 |
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Science advances |
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2022 Jun 17 |
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2021 Aug |
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation. |
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2021 Aug |
Vascular K(ATP) channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2021 Nov 2 |
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2021 Nov 8 |
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Nature structural & molecular biology |
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Nat Struct Mol Biol |
2022 Jul |
The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation. |
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Nature communications |
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Nat Commun |
2022 Mar 11 |
Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. |
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Nat Commun |
2021 Nov 1 |
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2021 Nov 4 |
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Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. |
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Nature communications |
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Nat Commun |
2024 Jan 17 |
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM. |
Fernandez-Ramirez MDC, Nguyen BA, Singh V, Afrin S, Evers B, Basset P, Wang L, Pękała M, Ahmed Y, Singh P, Canepa J, Wosztyl A, Li Y, Saelices L |
bioRxiv : the preprint server for biology |
38798519 |
bioRxiv |
2024 May 14 |
Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain. |
Childers KC, Cowper B, Vaughan JD, McGill JR, Davulcu O, Lollar P, Doering CB, Coxon CH, Spiegel PC Jr |
Journal of thrombosis and haemostasis : JTH |
38849084 |
J Thromb Haemost |
2024 Sep |
Structural and Biochemical Characterization of the Nucleosome Containing Variants H3.3 and H2A.Z. |
Jung H, Sokolova V, Lee G, Stevens VR, Tan D |
Epigenomes |
38920622 |
Epigenomes |
2024 May 27 |
Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin. |
Ye Q, Henrickson A, Demeler B, Balasco Serrão VH, Davies PL |
The Journal of biological chemistry |
39725035 |
J Biol Chem |
2025 Feb |
Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization. |
Lanning S, Aguilar-Hernández N, Serrão VHB, López T, O'Rourke SM, Lentz A, Ricemeyer L, Espinosa R, López S, Arias CF, DuBois RM |
bioRxiv : the preprint server for biology |
39314284 |
bioRxiv |
2024 Sep 14 |
P2X(7) receptors exhibit at least three modes of allosteric antagonism. |
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE |
Science advances |
39365862 |
Sci Adv |
2024 Oct 4 |
Cryo-EM analysis of Pseudomonas phage Pa193 structural components. |
Iglesias SM, Hou CD, Reid J, Schauer E, Geier R, Soriaga A, Sim L, Gao L, Whitelegge J, Kyme P, Birx D, Lemire S, Cingolani G |
Communications biology |
39370451 |
Commun Biol |
2024 Oct 6 |
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. |
Sharif H, Hollingsworth LR, Griswold AR, Hsiao JC, Wang Q, Bachovchin DA, Wu H |
Immunity |
34019797 |
Immunity |
2021 Jul 13 |
Tunable Heteroassembly of a Plant Pseudoenzyme-Enzyme Complex. |
Novikova IV, Zhou M, Du C, Parra M, Kim DN, VanAernum ZL, Shaw JB, Hellmann H, Wysocki VH, Evans JE |
ACS chemical biology |
34520180 |
ACS Chem Biol |
2021 Nov 19 |
Heat-dependent opening of TRPV1 in the presence of capsaicin. |
Kwon DH, Zhang F, Suo Y, Bouvette J, Borgnia MJ, Lee SY |
Nature structural & molecular biology |
34239123 |
Nat Struct Mol Biol |
2021 Jul |
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. |
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI |
Nature structural & molecular biology |
34239124 |
Nat Struct Mol Biol |
2021 Jul |
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. |
Grau D, Zhang Y, Lee CH, Valencia-Sánchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ |
Nature communications |
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Nat Commun |
2021 Jan 29 |
HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases. |
Rathinaswamy MK, Fleming KD, Dalwadi U, Pardon E, Harris NJ, Yip CK, Steyaert J, Burke JE |
Structure (London, England : 1993) |
34348129 |
Structure |
2021 Dec 2 |
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. |
Chen P, Zeng J, Liu Z, Thaker H, Wang S, Tian S, Zhang J, Tao L, Gutierrez CB, Xing L, Gerhard R, Huang L, Dong M, Jin R |
Nature communications |
34145250 |
Nat Commun |
2021 Jun 18 |
Superimmunity by pan-sarbecovirus nanobodies. |
Xiang Y, Huang W, Liu H, Sang Z, Nambulli S, Tubiana J, Williams KL Jr, Duprex WP, Schneidman-Duhovny D, Wilson IA, Taylor DJ, Shi Y |
Cell reports |
35738279 |
Cell Rep |
2022 Jun 28 |
Structure of the human cation-chloride cotransport KCC1 in an outward-open state. |
Zhao Y, Shen J, Wang Q, Ruiz Munevar MJ, Vidossich P, De Vivo M, Zhou M, Cao E |
Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2022 Jul 5 |
Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. |
Kwon DH, Zhang F, Fedor JG, Suo Y, Lee SY |
Nature communications |
35610228 |
Nat Commun |
2022 May 24 |
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP. |
Lopez-Redondo M, Fan S, Koide A, Koide S, Beckstein O, Stokes DL |
The Journal of general physiology |
34254979 |
J Gen Physiol |
2021 Aug 2 |
Chemical and structural investigation of the paroxetine-human serotonin transporter complex. |
Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E |
eLife |
32618269 |
Elife |
2020 Jul 3 |
The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states. |
Santosh V, Musayev FN, Jaiswal R, Zárate-Pérez F, Vandewinkel B, Dierckx C, Endicott M, Sharifi K, Dryden K, Henckaerts E, Escalante CR |
Nucleic acids research |
33270897 |
Nucleic Acids Res |
2020 Dec 16 |
Activation of human STING by a molecular glue-like compound. |
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Nature chemical biology |
37828400 |
Nat Chem Biol |
2024 Mar |
Cryo-EM structures reveal native GABA(A) receptor assemblies and pharmacology. |
Sun C, Zhu H, Clark S, Gouaux E |
Nature |
37730991 |
Nature |
2023 Oct |
Structural mechanisms for VMAT2 inhibition by tetrabenazine. |
Dalton MP, Cheng MH, Bahar I, Coleman JA |
bioRxiv : the preprint server for biology |
37732203 |
bioRxiv |
2024 Feb 1 |
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain. |
Harris NJ, Jenkins ML, Nam SE, Rathinaswamy MK, Parson MA, Ranga-Prasad H, Dalwadi U, Moeller BE, Sheekey E, Hansen SD, Yip CK, Burke JE |
bioRxiv : the preprint server for biology |
37090531 |
bioRxiv |
2023 May 23 |
A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM. |
Langeberg CJ, Kieft JS |
Nucleic acids research |
37791881 |
Nucleic Acids Res |
2023 Nov 10 |
Nodavirus RNA replication crown architecture reveals proto-crown precursor and viral protein A conformational switching. |
Zhan H, Unchwaniwala N, Rebolledo-Viveros A, Pennington J, Horswill M, Broadberry R, Myers J, den Boon JA, Grant T, Ahlquist P |
Proceedings of the National Academy of Sciences of the United States of America |
36693094 |
Proc Natl Acad Sci U S A |
2023 Jan 31 |
Adeno-Associated Virus (AAV-DJ)-Cryo-EM Structure at 1.56 Å Resolution. |
Xie Q, Yoshioka CK, Chapman MS |
Viruses |
33092282 |
Viruses |
2020 Oct 20 |
Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter. |
Thaker TM, Mishra S, Zhou W, Mohan M, Tang Q, Faraldo-Goméz JD, Mchaourab HS, Tomasiak TM |
Nature chemical biology |
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Nat Chem Biol |
2022 Feb |
Computational design of mechanically coupled axle-rotor protein assemblies. |
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Science (New York, N.Y.) |
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Science |
2022 Apr 22 |
Structural mechanism of muscle nicotinic receptor desensitization and block by curare. |
Rahman MM, Basta T, Teng J, Lee M, Worrell BT, Stowell MHB, Hibbs RE |
Nature structural & molecular biology |
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Nat Struct Mol Biol |
2022 Apr |
Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria. |
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Nature communications |
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Nat Commun |
2022 Oct 3 |
Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA. |
Bonilla SL, Vicens Q, Kieft JS |
Science advances |
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Sci Adv |
2022 Aug 26 |
Cross-protective antibodies against common endemic respiratory viruses. |
Cabán M, Rodarte JV, Bibby M, Gray MD, Taylor JJ, Pancera M, Boonyaratanakornkit J |
Nature communications |
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Nat Commun |
2023 Feb 13 |
Inhibition of the proton-activated chloride channel PAC by PIP(2). |
Mihaljević L, Ruan Z, Osei-Owusu J, Lü W, Qiu Z |
eLife |
36633397 |
Elife |
2023 Jan 12 |
Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1. |
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO |
Structure (London, England : 1993) |
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2023 Mar 2 |
Structural mechanisms for VMAT2 inhibition by tetrabenazine. |
Dalton MP, Cheng MH, Bahar I, Coleman JA |
eLife |
38517752 |
Elife |
2024 Mar 22 |
Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM. |
McFarland R, Reichow S |
bioRxiv : the preprint server for biology |
38585788 |
bioRxiv |
2024 Mar 27 |
Structural basis of TFIIIC-dependent RNA Polymerase III transcription initiation. |
Talyzina A, Han Y, Banerjee C, Fishbain S, Reyes A, Vafabakhsh R, He Y |
bioRxiv : the preprint server for biology |
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bioRxiv |
2023 May 16 |
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC. |
Srinivas P, Nosrati M, Zelinskaya N, Dey D, Comstock LR, Dunham CM, Conn GL |
Proceedings of the National Academy of Sciences of the United States of America |
37307464 |
Proc Natl Acad Sci U S A |
2023 Jun 20 |
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. |
Li M, Oliveira Passos D, Shan Z, Smith SJ, Sun Q, Biswas A, Choudhuri I, Strutzenberg TS, Haldane A, Deng N, Li Z, Zhao XZ, Briganti L, Kvaratskhelia M, Burke TR Jr, Levy RM, Hughes SH, Craigie R, Lyumkis D |
Science advances |
37478179 |
Sci Adv |
2023 Jul 21 |
TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. |
Kwon DH, Zhang F, McCray BA, Feng S, Kumar M, Sullivan JM, Im W, Sumner CJ, Lee SY |
Nature communications |
37353484 |
Nat Commun |
2023 Jun 23 |
Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2023 Jul 18 |
Structure of an endogenous mycobacterial MCE lipid transporter. |
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Research square |
36711512 |
Res Sq |
2023 Jan 10 |
Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor. |
Mazzaferro S, Kang G, Natarajan K, Hibbs RE, Sine SM |
British journal of pharmacology |
38454578 |
Br J Pharmacol |
2024 Jul |
Human calpain-3 and its structural plasticity: dissociation of a homohexamer into dimers on binding titin. |
Ye Q, Henrickson A, Demeler B, Serrão VHB, Davies PL |
bioRxiv : the preprint server for biology |
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bioRxiv |
2024 Mar 3 |
VitroJet: new features and case studies. |
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Acta crystallographica. Section D, Structural biology |
38488730 |
Acta Crystallogr D Struct Biol |
2024 Apr 1 |
A suite of designed protein cages using machine learning and protein fragment-based protocols. |
Meador K, Castells-Graells R, Aguirre R, Sawaya MR, Arbing MA, Sherman T, Senarathne C, Yeates TO |
Structure (London, England : 1993) |
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2024 Jun 6 |
Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter. |
Souza Amado de Carvalho R, Rasel MSI, Khandelwal NK, Tomasiak TM |
Life science alliance |
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Life Sci Alliance |
2024 Nov |
Structural transitions enable interleukin-18 maturation and signaling. |
Dong Y, Bonin JP, Devant P, Liang Z, Sever AIM, Mintseris J, Aramini JM, Du G, Gygi SP, Kagan JC, Kay LE, Wu H |
Immunity |
38733997 |
Immunity |
2024 Jul 9 |
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies. |
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR 3rd, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD |
Science (New York, N.Y.) |
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Science |
2024 May 17 |
Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation. |
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE |
Cell |
38382524 |
Cell |
2024 Feb 29 |
Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor. |
Childers KC, Avery NG, Estrada Alamo KA, Davulcu O, Haynes RM, Lollar P, Doering CB, Coxon CH, Spiegel PC |
Blood |
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Blood |
2023 Jul 13 |
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. |
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Proceedings of the National Academy of Sciences of the United States of America |
38150499 |
Proc Natl Acad Sci U S A |
2024 Jan 2 |
Mechanism of anion exchange and small-molecule inhibition of pendrin. |
Wang L, Hoang A, Gil-Iturbe E, Laganowsky A, Quick M, Zhou M |
Nature communications |
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Nat Commun |
2024 Jan 6 |
Structural basis for flagellin-induced NAIP5 activation. |
Paidimuddala B, Cao J, Zhang L |
Science advances |
38055825 |
Sci Adv |
2023 Dec 8 |
Priming antibody responses to the fusion peptide in rhesus macaques. |
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NPJ vaccines |
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NPJ Vaccines |
2024 Jul 12 |
Structural basis for transcription activation through cooperative recruitment of MntR. |
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Research square |
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2024 Jul 15 |
Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain. |
Wu W, Kumar P, Brautigam CA, Tso SC, Baniasadi HR, Kober DL, Gilles-Gonzalez MA |
bioRxiv : the preprint server for biology |
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bioRxiv |
2024 Jul 24 |
Structures of methane and ammonia monooxygenases in native membranes. |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2025 Jan 7 |
Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision. |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2025 Jan 7 |
Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy. |
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Scientific reports |
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Sci Rep |
2025 Jan 2 |
Molecular basis of the urate transporter URAT1 inhibition by gout drugs. |
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bioRxiv : the preprint server for biology |
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bioRxiv |
2024 Sep 12 |
The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly. |
Schubert HL, Li F, Hill CP, Schmidt EW |
Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2025 Feb 11 |
Structural and functional characterization of capsid binding by anti-AAV9 monoclonal antibodies from infants after SMA gene therapy. |
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Molecular therapy : the journal of the American Society of Gene Therapy |
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Mol Ther |
2023 Jul 5 |
Molecular architecture of the Chikungunya virus replication complex. |
Tan YB, Chmielewski D, Law MCY, Zhang K, He Y, Chen M, Jin J, Luo D |
Science advances |
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Sci Adv |
2022 Dec 2 |
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. |
Doran MH, Rynkiewicz MJ, Pavadai E, Bodt SML, Rasicci D, Moore JR, Yengo CM, Bullitt E, Lehman W |
The Journal of general physiology |
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J Gen Physiol |
2023 Feb 6 |
Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core. |
Richards LS, Flores MD, Zink S, Schibrowsky NA, Sawaya MR, Rodriguez JA |
bioRxiv : the preprint server for biology |
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bioRxiv |
2023 Feb 11 |
Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. |
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI |
Nature structural & molecular biology |
37653241 |
Nat Struct Mol Biol |
2023 Oct |
Engineered odorant receptors illuminate structural principles of odor discrimination. |
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bioRxiv : the preprint server for biology |
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bioRxiv |
2023 Nov 17 |
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. |
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M |
eLife |
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Elife |
2024 Feb 12 |
A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase. |
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Nature communications |
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Nat Commun |
2023 Dec 12 |
CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism. |
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie G, Bois JD, Dror RO, Chiu W, Maduke M |
bioRxiv : the preprint server for biology |
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bioRxiv |
2023 Nov 29 |
Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. |
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Biophysical journal |
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Biophys J |
2020 Aug 18 |
Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. |
Fan M, Zhang J, Lee CL, Zhang J, Feng L |
Nature |
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Nature |
2023 Feb |
Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. |
Gangwar SP, Yen LY, Yelshanskaya MV, Sobolevsky AI |
Cell reports |
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Cell Rep |
2023 Feb 28 |
Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2024 Mar 5 |
Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies. |
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Nature microbiology |
38858594 |
Nat Microbiol |
2024 Aug |
Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor. |
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Nature communications |
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Nat Commun |
2024 Oct 1 |
Molecular basis of proton sensing by G protein-coupled receptors. |
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Cell |
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2025 Feb 6 |
The Structural, Biophysical, and Antigenic Characterization of the Goose Parvovirus Capsid. |
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2025 Jan 3 |
Complex Water Networks Visualized through 2.2-2.3 Å Cryogenic Electron Microscopy of RNA. |
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bioRxiv : the preprint server for biology |
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bioRxiv |
2025 Jan 24 |
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. |
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Cell |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2022 Sep 13 |
Three-dimensional structure-guided evolution of a ribosome with tethered subunits. |
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Nature chemical biology |
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Nat Chem Biol |
2022 Sep |
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. |
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Nature structural & molecular biology |
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Nat Struct Mol Biol |
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bioRxiv : the preprint server for biology |
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2023 Nov 25 |
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2022 Dec 26 |
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2023 Feb |
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2023 Nov 2 |
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Nature communications |
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2025 Jan 21 |
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Nature structural & molecular biology |
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Nature structural & molecular biology |
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Proceedings of the National Academy of Sciences of the United States of America |
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Proc Natl Acad Sci U S A |
2022 Apr 12 |
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Nature communications |
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2023 Oct 23 |
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2023 Aug 26 |
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Nature structural & molecular biology |
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Nat Struct Mol Biol |
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Nature communications |
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Nature structural & molecular biology |
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Science (New York, N.Y.) |
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bioRxiv : the preprint server for biology |
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Nature communications |
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2023 Feb |
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Nature communications |
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Molecular cell |
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Proceedings of the National Academy of Sciences of the United States of America |
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2021 Mar 23 |
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PLoS Biol |
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Cell host & microbe |
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Cell Host Microbe |
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Cell |
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2021 May 27 |
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Nucleic acids research |
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Nucleic Acids Res |
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Nature structural & molecular biology |
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Nat Struct Mol Biol |
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Nature structural & molecular biology |
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Nat Struct Mol Biol |
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Proceedings of the National Academy of Sciences of the United States of America |
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Nature structural & molecular biology |
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2021 Sep 14 |
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Nature communications |
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Nat Commun |
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Sci Adv |
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Cell |
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Cell |
2024 Sep 19 |
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies. |
Edman NI, Redler RL, Phal A, Schlichthaerle T, Srivatsan SR, Etemadi A, An SJ, Favor A, Ehnes D, Li Z, Praetorius F, Gordon M, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D |
bioRxiv : the preprint server for biology |
36993355 |
bioRxiv |
2023 Mar 15 |
Structures of the promoter-bound respiratory syncytial virus polymerase. |
Cao D, Gao Y, Chen Z, Gooneratne I, Roesler C, Mera C, D'Cunha P, Antonova A, Katta D, Romanelli S, Wang Q, Rice S, Lemons W, Ramanathan A, Liang B |
Nature |
38123676 |
Nature |
2024 Jan |
Molecular Basis of Human Trace Amine-Associated Receptor 1 Activation. |
Zilberg G, Parpounas AK, Warren AL, Yang S, Wacker D |
bioRxiv : the preprint server for biology |
37986760 |
bioRxiv |
2023 Sep 7 |
CryoCycle your grids: Plunge vitrifying and reusing clipped grids to advance cryoEM democratization. |
Serbynovskyi V, Wang J, Chua EY, Ishemgulova A, Alink LM, Budell WC, Johnston JD, Dubbeldam C, Gonzalez FA, Rozovsky S, Eng ET, de Marco A, Noble AJ |
Research square |
39011111 |
Res Sq |
2024 Jul 2 |
Mechanisms of actin filament severing and elongation by formins. |
Palmer NJ, Barrie KR, Dominguez R |
Nature |
38843827 |
Nature |
2024 Aug |
DISTANT RIBOSE 2'-O-METHYLATION OF 23S rRNA HELIX 69 PRE-ORDERS THE CAPREOMYCIN DRUG BINDING POCKET AT THE RIBOSOME SUBUNIT INTERFACE. |
Nandi S, Dey D, Srinivas P, Dunham CM, Conn GL |
bioRxiv : the preprint server for biology |
39574593 |
bioRxiv |
2024 Nov 5 |
Mechanism of Nucleotide-Dependent Allosteric Regulation in Escherichia coli Aspartate Transcarbamoylase. |
Miller RC, Patterson MG, Bhatt N, Pei X, Ando N |
bioRxiv : the preprint server for biology |
39605687 |
bioRxiv |
2024 Nov 20 |
Structure-function analyses of human TRPV6 ancestral and derived haplotypes. |
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI |
Structure (London, England : 1993) |
39500315 |
Structure |
2025 Jan 2 |
Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography. |
Zhou H, Hutchings J, Shiozaki M, Zhao X, Doolittle LK, Yang S, Yan R, Jean N, Riggi M, Yu Z, Villa E, Rosen MK |
bioRxiv : the preprint server for biology |
39677698 |
bioRxiv |
2024 Dec 31 |
Structural basis of archaeal FttA-dependent transcription termination. |
You L, Wang C, Molodtsov V, Kuznedelov K, Miao X, Wenck BR, Ulisse P, Sanders TJ, Marshall CJ, Firlar E, Kaelber JT, Santangelo TJ, Ebright RH |
Nature |
39322680 |
Nature |
2024 Nov |
Two Forms of Thick Filament in the Flight Muscle of Drosophila melanogaster. |
Rastegarpouyani H, Hojjatian A, Taylor KA |
International journal of molecular sciences |
39457097 |
Int J Mol Sci |
2024 Oct 21 |
A structure-based mechanism for initiation of AP-3 coated vesicle formation. |
Begley M, Aragon M, Baker RW |
Proceedings of the National Academy of Sciences of the United States of America |
39705307 |
Proc Natl Acad Sci U S A |
2024 Dec 24 |
Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryoEM and MD simulations. |
Mancl JM, Wu X, Zhao M, Tang WJ |
bioRxiv : the preprint server for biology |
39868314 |
bioRxiv |
2025 Jan 19 |
Development of CryoVR, a virtual reality training system for hands-on cryoEM operations. |
Dong J, Li D, Ozcan K, Wan D, Jiang W, Chen Y |
Acta crystallographica. Section D, Structural biology |
35775989 |
Acta Crystallogr D Struct Biol |
2022 Jul 1 |
ManiLoco: A VR-Based Locomotion Method for Concurrent Object Manipulation. |
Wan D, Guo X, Dong J, Mousas C, Chen Y |
Proceedings of the ACM on computer graphics and interactive techniques |
37293199 |
Proc ACM Comput Graph Interact Tech |
2023 May |
Understanding Pitfalls and Opportunities of Applying Heuristic Evaluation Methods to VR Training Systems: An Empirical Study. |
Guo X, Nerella KK, Dong J, Qian Z, Chen Y |
International journal of human-computer interaction |
38863735 |
Int J Hum Comput Interact |
2024 |
Video Captioning Using Global-Local Representation. |
Yan L, Ma S, Wang Q, Chen Y, Zhang X, Savakis A, Liu D |
IEEE transactions on circuits and systems for video technology : a publication of the Circuits and Systems Society |
37215187 |
IEEE Trans Circuits Syst Video Technol |
2022 Oct |
Computational Methods for Single-Particle Electron Cryomicroscopy. |
Singer A, Sigworth FJ |
Annual review of biomedical data science |
34485850 |
Annu Rev Biomed Data Sci |
2020 Jul |
Lysate-to-grid: Rapid Isolation of Native Complexes from Budding Yeast for Cryo-EM Imaging. |
Cooney I, Mack DC, Ferrell AJ, Stewart MG, Wang S, Donelick HM, Tamayo-Jaramillo D, Greer DL, Zhu D, Li W, Shen PS |
Bio-protocol |
36789166 |
Bio Protoc |
2023 Jan 20 |
Protocol to study CCT-mediated folding of Gβ(5) by single-particle cryo-EM. |
Sass MI, Wang S, Mack D, Cottam SL, Shen PS, Willardson BM |
STAR protocols |
38848218 |
STAR Protoc |
2024 Jun 21 |